Overview of Picked Chemical Compounds and Intermediates
Overview of Picked Chemical Compounds and Intermediates
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one. Pharmaceutical Intermediates
Bortezomib Acid Impurity: This really is an impurity relevant to bortezomib, a proteasome inhibitor Employed in the treatment of numerous myeloma. Its synthesis or study is crucial for ensuring the purity and protection on the drug.
Abiraterone Acetate Intermediate (CAS NO. 122111-01-7): A precursor during the synthesis of abiraterone acetate, a drug Utilized in the remedy of prostate most cancers by inhibiting androgen manufacturing.
Imatinib Intermediate (CAS NO. 152460-10-one): A crucial compound inside the synthesis of imatinib, a drug that targets specific different types of cancer, including Continual myelogenous leukemia (CML).
Docetaxel Intermediate: A compound used in the synthesis of docetaxel, a chemotherapy medication that treats a variety of cancers like breast, lung, and prostate most cancers.
two. Chemical Impurities and Byproducts
GeMcitabine Intermediates (T6, T9, eight): These are definitely intermediates while in the synthesis of gemcitabine, an anti-most cancers drug. Their examine is vital for optimizing the output method and making sure substantial purity.
Lapatinib Intermediate (CAS NO. 231278-84-5): Lapatinib is made use of to deal with breast cancer, 1-AMINO-3-ADAMANTANOL and these intermediates are associated with its output.
Fulvestrant Intermediates: Fulvestrant is surely an estrogen receptor antagonist Employed in the remedy of breast most cancers. Various intermediates assist in the synthesis of the drug.
Paclitaxel Facet Chain Acid (CAS NO. 949023-16-nine): This intermediate is used in the synthesis of paclitaxel, a chemotherapy drug productive in dealing with cancers for instance ovarian, breast, and lung most cancers.
three. Other Noteworthy Compounds
Irinotecan Hydrochloride Trihydrate (CAS NO. 136572-09-three): A chemotherapy drug used in the procedure of colorectal cancer and modest mobile lung cancer.
three-Amino-one-hydroxyadamantane (CAS 702-82-9): This compound is involved in the synthesis of adamantane derivatives, which have several applications, like antiviral Attributes.
Vildagliptin Intermediates: Used in the production of 5-dibenzoate(T6) vildagliptin, an oral drug for sort two diabetes that inhibits the enzyme DPP-4 to manage blood sugar stages.
4. Miscellaneous Compounds
D-Gluconic Acid δ-Lactone (CAS NO. 61259-forty eight-1): This compound is associated with the synthesis of varied gluconic acid derivatives, which are Utilized in foodstuff, pharmaceutical, and industrial purposes.
Canagliflozin Intermediate two: A precursor in the synthesis of canagliflozin, a medication utilized to manage type two diabetic issues by inhibiting sodium-glucose co-transporter 2 (SGLT2).